看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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& u/ n, A5 l! ] R+ O; ZCurrently available feasibility data for possible combination strategies.
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Combination Feasibility according to preliminary data " E- f$ j7 U6 W. w
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Bevacizumab + sorafenib Yes, reduced dose
{$ F f" p( m- i/ N( y" f. nBevacizumab + sunitinib† No # Q9 [$ @" f% B
Bevacizumab + temsirolimus Yes : X7 x3 V6 _! e- j% x
Bevacizumab + everolimus Yes
: l5 z/ R- ]0 U# O) j1 t! NSorafenib + sunitinib ?
% M. K) R o* a& HSorafenib + temsirolimus Yes, reduced dose % ?8 e1 a6 a! }6 ^. C
Sorafenib + everolimus Yes, reduced dose
3 h2 F1 t9 u! M4 ]% v/ YSunitinib + temsirolimus† No . v8 T3 d- F8 ^1 ~. `6 p5 T! j
Sunitinib + everolimus ? " K, J* ~6 v& l1 c! D5 Z, H
Temsirolimus + everolimus ? ; W C5 h, x. h
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†Led to US FDA warning.
v" Q' k$ D8 J1 X& r?: As yet unattempted combination.0 n3 t1 {6 E; \6 D
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