看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。: Q5 P4 J2 U1 e0 I. c
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Currently available feasibility data for possible combination strategies. 2 r' ~( F* A7 ?& m& b
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6 v% u7 s7 M% O5 ?' }2 ^Combination Feasibility according to preliminary data ( e" v# J8 o9 k3 X% q5 I C
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! b" h" p3 Q5 b" y1 C# N0 t' ?Bevacizumab + sorafenib Yes, reduced dose * F/ t' k* x* K/ z7 t6 U
Bevacizumab + sunitinib† No 9 s4 }; v4 a' Y w& V5 [
Bevacizumab + temsirolimus Yes ; |" E0 r0 C K
Bevacizumab + everolimus Yes $ h+ A! e) Z/ m3 R: j1 H N
Sorafenib + sunitinib ?
# @; l5 D9 d# \- USorafenib + temsirolimus Yes, reduced dose " h1 r/ _: g3 x. I- D2 [
Sorafenib + everolimus Yes, reduced dose
: m+ ^% \$ x2 NSunitinib + temsirolimus† No 3 B. S. s$ U1 f% a4 N& R
Sunitinib + everolimus ? + C/ H/ ]0 o. K' W5 H( Z
Temsirolimus + everolimus ?
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6 m' r2 g7 c* D$ a7 ^, x6 U% g†Led to US FDA warning., p/ ~ T$ X8 C3 ^5 v9 E
?: As yet unattempted combination.8 V H$ k% m) l* u% e; C
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