! v; A* { Y( _# r- n, F" K+ W“The basic idea is to take patient whose cancer has grown on tarceva, do cyberknife to the spots that have grown to eliminate the resistant clones, then continue using tarceva for the rest of the cancer that has shown evidence for ongoing sensitivity to tarceva.” 2 P8 T: r* F8 L8 {* s& P6 z0 _基本理念就是特耐药后,要看是如何耐药的,如果一些肿瘤没变化,只有个别肿瘤长大,说明特是有效的;这种情况耐药,就用射波刀来处理在服特(或其它靶向药)期间长大的肿瘤,然后继续使用特来对付那些显示敏感的肿瘤细胞。 , [/ u9 t& V# `2 M$ E) n# x4 X1 k. E. w
“When cancer grows through chemotherapy, it often grows in multiple spots and generates new spots. In contrast, when EGFR-mutated lung cancer grows through tarceva, a good portion of the time it only grows in one or two spots. Recent breakthroughs have shown some of the mechanisms of this resistance.”# D; e' H7 [6 b8 K: i) R5 ?% p9 b" {( _
化疗后若肿瘤继续进展,通常是多处增大并有新的转移;相反,如果用特期间基因突变的肿瘤在进展,往往仅限于一处或两处,最新的突破性研究显示了这些耐药机制。 + E3 p5 Q$ h5 j+ R2 |6 O9 I+ {/ X7 z9 A
“The key point that I want to make is that progression is often limited. Often, most of the cancer cells remain sensitive to tarceva while one or two spots acquire some change (with “some change” partially defined in the figure above and in Dr. Sequists’s webinar). In theory, if you could eliminate those few spots of resistance, you can imagine that the remainder of the cancer in the body might be well controlled back on tarceva. That’s the core idea here.”8 Q' T% x6 g* `) G& s# ^
我想表达的一个重点是:耐药的进展是有限的。通常大部分的肿瘤细胞对特还是敏感的,只有一小部分没有控制到。理论上,如果你能有效地消灭一小部分有耐药的肿瘤细胞,我们可以想象特完全有能力控制其余的肿瘤细胞。这就是本文讨论的要点! 0 ^+ r T/ V/ E. l% p
! Z8 E1 M, q+ q0 e- U D, i2、在病情稳定期间,不能被动地维持稳定,要积极主动、想方设法提升加强免疫系统,可耐受内的大运动量相当重要:一是出汗排毒,二是提升干细胞的战斗力。大家都觉得郭林气功对治病有用,我想其中是三个理由:一是运动(但我觉得运动量不够),二是静心忘我,三是吸氧保持血氧浓度。 * k( Y! I( @- T0 B2 n w3 `: \/ a, v3、任何从生理上及心理上有利于提升免疫系统的自然、有机疗法,都值得去试;吃一些能有效改善和提升免疫系统的有机食物(品),还有我们一直提倡身心快乐、愉悦,也是激发提升免疫系统的最有效的方法,而且是免费的。/ j* ]1 z7 g H
: ? k1 p) @9 D4、以上吃也好,运动也好、保持乐观心态、积极心情也好,都不能达成免疫系统的“正突变”,最终可能还是要走进“四大皆空”境界。。。如何走,能否做到?大家各自性格、环境和个体差异不一样,只能是八仙过海,各显神通!走到了,也许就成功了!. ~0 Y& B5 J; F% t f, o7 e( d3 B/ j" p
% |8 \% G% j9 d+ V5、要进入“四大皆空”,能否采用休眠疗法呢!?但这种是“非主观意识下”的状态,是否能激发免疫系统的“正突变”,只是突发奇想! 2 J* h x) J. L# { , | Y9 m+ S! @+ o( M以上抛砖引玉,请大家一起来探讨,如何达成“正突变”!?; u) U J4 }5 _7 W1 m" T
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