发给老马备查:
( @ h0 ~7 v2 I滴水察海(69304838) 15:23:23
" j' ^; f9 R$ u6 @老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱+ {& z. I# l2 w g( I/ o, S K
吉非替尼和S-1连用的依据 h; Y, S! j# ?8 f
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
) V! m& ^1 Z, B, A( X. Q" `是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
9 A( G# X7 \9 H. ^" R这样是不是推理出,耐药后,可以用S-1和培美了?
c$ G; _# m/ j2 \3 R3 E) @8 K3 x+ H结论:0 {. I6 [5 g5 W' h/ U
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |