发给老马备查:
& f/ V0 @7 v0 G* N8 r7 B, j; Z. z滴水察海(69304838) 15:23:23" M: Z$ R2 T: b, Q) ~4 ~
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
) c1 d. W" n: t吉非替尼和S-1连用的依据
! @) k2 w5 d; V, z/ uGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro." ~$ l( v7 i8 Z
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
9 \5 A3 }( N; ]/ R+ ]1 S这样是不是推理出,耐药后,可以用S-1和培美了?
8 B* G( ]( v+ P! E8 v8 B1 R2 W4 e结论:7 L$ l1 p% _- w3 O0 ]6 ?# r1 D
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |