发给老马备查: . g! h' r8 ? }; R- `( t- U- {" H滴水察海(69304838) 15:23:23 6 D3 M% q a8 W9 I' Y" u' J' g! t老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱 ) I6 c( I6 j0 H8 D( F吉非替尼和S-1连用的依据 + {# k7 ], G) {6 u8 s3 pGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.3 d& _1 Y' o' n9 Q
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达! y1 D' R& x% M) |
这样是不是推理出,耐药后,可以用S-1和培美了? 0 g; O. l, @' _5 \结论:( [5 M) `, \9 ]5 [* U) q( O
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。